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On the other hand, the development of carrier-based DPI formulations usually focuses on carrier particle engineering to address the challenge of poor drug-carrier detachment (to aid and/or reduce interaction between drug and carrier particles) and improved lung drug deposition (increased fine particle fraction, FPF)

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The main risk is hypoglycemia (dangerously low blood sugar), which can become a medical emergency

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Second, niacinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme central to cellular energy metabolism, mitochondrial function, and DNA repair

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